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Data showing chemical compositions of the essential oils of the leaves of Cymbopogon citratus obtained by varying pH of the extraction medium.

ABSTRACT: This article describes the various chemical components as obtained from the oils in the leaves of Cymbopogon citratus using hydrodistillation and solvent-free microwave extraction methods. Furthermore, extractions of the oils were also carried out with a slight in pH variation and compared, "GC-MS evaluation of C. citratus (DC) Stapf oil obtained using modified hydrodistillation and microwave extraction methods" (Ajayi et al., 2016 [1]). The current article contains one table exhibiting a list of compounds in the four different methods of extraction. Comparative studies amongst the various methods of extraction are highlighted in the table.

SUBMITTER: Ajayi EO

PROVIDER: S-EPMC4936328 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Data showing chemical compositions of the essential oils of the leaves of Cymbopogon citratus obtained by varying pH of the extraction medium.

Ajayi E O EO Sadimenko A P AP Afolayan A J AJ

Data in brief 20160622

This article describes the various chemical components as obtained from the oils in the leaves of Cymbopogon citratus using hydrodistillation and solvent-free microwave extraction methods. Furthermore, extractions of the oils were also carried out with a slight in pH variation and compared, "GC-MS evaluation of C. citratus (DC) Stapf oil obtained using modified hydrodistillation and microwave extraction methods" (Ajayi et al., 2016 [1]). The current article contains one table exhibiting a list o ...[more]

PMID: 27419197

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Project description:Acetylcholinesterase (AChE) has been an effective target for insecticide development which is a very important aspect of the global fight against insect-borne diseases. The drastic reduction in the sensitivity of insects to AChE-targeting insecticides like organophosphates and carbamates have increased the need for insecticides of natural origin. In this study, we used Drosophila melanogaster as a model to investigate the insecticidal and AChE inhibitory potentials of Cymbopogon citratus and its bioactive compounds. Flies were exposed to 100 and 200 mg/mL C. citratus leaf extract for a 3-h survival assay followed by 45 min exposure for negative geotaxis and biochemical assays. Molecular docking analysis of 45 bioactive compounds of the plant was conducted against Drosophila melanogaster AChE (DmAChE). Exposure to C. citratus significantly reduced the survival rate of flies throughout the exposure period and this was accompanied by a significant decrease in percentage negative geotaxis, AChE activity, catalase activity, total thiol level and a significant increase in glutathione-S-transferase (GST) activity. The bioactive compounds of C. citratus showed varying levels of binding affinities for the enzyme. (+)-Cymbodiacetal scored highest (−9.407 kcal/mol) followed by proximadiol (−8.253 kcal/mol), geranylacetone (−8.177 kcal/mol), and rutin (−8.148 kcal/mol). The four compounds occupied the same binding pocket and interacted with important active site amino acid residues as the co-crystallized ligand (1qon). These compounds could be responsible for the insecticidal and AChE inhibitory potentials of C. citratus and they could be further explored in the development of AChE-targeting insecticides. Highlights • Cymbopogon citratus reduced the AChE activity, catalase activity, total thiol level in Drosophilia melanogaster.• The bioactive compounds of Cymbopogon citratus displayed considerable binding affinities for Drosophila melanogaster AChE and the four top-scoring compounds are (+)-Cymbodiacetal, proximadiol, geranylacetone, and rutin.• (+)-Cymbodiacetal showed the highest binding affinity to AChE (DmAChE).

Dataset Information

Data showing chemical compositions of the essential oils of the leaves of Cymbopogon citratus obtained by varying pH of the extraction medium.

Publications

Data showing chemical compositions of the essential oils of the leaves of Cymbopogon citratus obtained by varying pH of the extraction medium.

Similar Datasets

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