Ontology highlight
ABSTRACT:
SUBMITTER: Li YL
PROVIDER: S-EPMC4936896 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
eLife 20160602
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids. Efficient capsid recognition also requires the conserved N-terminal tripartite motifs (TRIM), which mediate oligomerization and create avidity effects. To characterize how TRIM5 proteins recognize viral capsids, we developed method ...[more]