LncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells and inhibits tumor growth in vivo.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4938146 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
LncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells and inhibits tumor growth in vivo.
Chen Long L Yang Huixin H Xiao Yanbin Y Tang Xiaoxia X Li Yuqian Y Han Qiaoqiao Q Fu Junping J Yang Yuye Y Zhu Yuechun Y
OncoTargets and therapy 20160704
The present study intended to demonstrate the effects of long noncoding RNA growth arrest-specific transcript 5 (GAS5) on the migration and invasion of melanoma cells. We first detected the expression of GAS5 among four kinds of melanoma cell lines, followed by constructing GAS5-knocked down and overexpressed stable cells. Next, we evaluated the effects of GAS5 on cell migration and invasion using wound healing and gelatin zymography assays. Finally, melanoma cells with different GAS5 expression ...[more]
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