Ontology highlight
ABSTRACT:
SUBMITTER: Chotprakaikiat W
PROVIDER: S-EPMC4938312 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Chotprakaikiat Warayut W Allen Alex A Bui-Minh Duc D Harden Elena E Jobsri Jantipa J Cavallo Federica F Gleba Yuri Y Stevenson Freda K FK Ottensmeier Christian C Klimyuk Victor V Savelyeva Natalia N
Oncoimmunology 20160422 6
Passive antibody therapy for cancer is an effective but costly treatment modality. Induction of therapeutically potent anticancer antibodies by active vaccination is an attractive alternative but has proven challenging in cancer due to tolerogenic pressure in patients. Here, we used the clinically relevant cancer target Her2, known to be susceptible to targeting by antibody therapy, to demonstrate how potent antibody can be induced by vaccination. A novel 44kD Her2 protein fragment was generated ...[more]