Atg3 Overexpression Enhances Bortezomib-Induced Cell Death in SKM-1 Cell.

ABSTRACT:

Background

Myelodysplastic syndrome (MDS) is a group of heterogeneous hematopoietic stem cell malignancies with a high risk of transformation into acute myeloid leukemia (AML). Clonal evolutions are significantly associated with transformation to AML. According to a gene expression microarray, atg3 is downregulated in MDS patients progressing to leukemia, but less is known about the function of Atg3 in the survival and death of MSD/AML cells. Moreover, the role of autophagy as a result of bortezomib treatment is controversial. The current study was designed to investigate the function of Atg3 in SKM-1 cells and to study the effect of Atg3 on cell viability and cell death following bortezomib treatment.

Methods

Four leukemia cell lines (SKM-1, THP-1, NB4 and K562) and two hea

SUBMITTER: Zhuang L 

PROVIDER: S-EPMC4938461 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature