Ontology highlight
ABSTRACT:
SUBMITTER: Ye H
PROVIDER: S-EPMC4938766 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Ye Haobin H Adane Biniam B Khan Nabilah N Sullivan Timothy T Minhajuddin Mohammad M Gasparetto Maura M Stevens Brett B Pei Shanshan S Balys Marlene M Ashton John M JM Klemm Dwight J DJ Woolthuis Carolien M CM Stranahan Alec W AW Park Christopher Y CY Jordan Craig T CT
Cell stem cell 20160630 1
Adipose tissue (AT) has previously been identified as an extra-medullary reservoir for normal hematopoietic stem cells (HSCs) and may promote tumor development. Here, we show that a subpopulation of leukemic stem cells (LSCs) can utilize gonadal adipose tissue (GAT) as a niche to support their metabolism and evade chemotherapy. In a mouse model of blast crisis chronic myeloid leukemia (CML), adipose-resident LSCs exhibit a pro-inflammatory phenotype and induce lipolysis in GAT. GAT lipolysis fue ...[more]