Ontology highlight
ABSTRACT:
SUBMITTER: Nakano Y
PROVIDER: S-EPMC4939605 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nakano Yasuhiro Y Matoba Tetsuya T Tokutome Masaki M Funamoto Daiki D Katsuki Shunsuke S Ikeda Gentaro G Nagaoka Kazuhiro K Ishikita Ayako A Nakano Kaku K Koga Jun-Ichiro J Sunagawa Kenji K Egashira Kensuke K
Scientific reports 20160711
Myocardial ischemia-reperfusion (IR) injury limits the therapeutic effect of early reperfusion therapy for acute myocardial infarction (AMI), in which the recruitment of inflammatory monocytes plays a causative role. Here we develop bioabsorbable poly-lactic/glycolic acid (PLGA) nanoparticles incorporating irbesartan, an angiotensin II type 1 receptor blocker with a peroxisome proliferator-activated receptor (PPAR)γ agonistic effect (irbesartan-NP). In a mouse model of IR injury, intravenous PLG ...[more]