Ontology highlight
ABSTRACT:
SUBMITTER: Ricles LM
PROVIDER: S-EPMC4939799 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Ricles Laura M LM Hsieh Pei-Ling PL Dana Nicholas N Rybalko Viktoriya V Kraynak Chelsea C Farrar Roger P RP Suggs Laura J LJ
Biomaterials 20160607
The intent of the current study was to investigate the therapeutic contribution of MSCs to vascular regeneration and functional recovery of ischemic tissue. We used a rodent hind limb ischemia model and intramuscularly delivered MSCs within a PEGylated fibrin gel matrix. Within this model, we demonstrated that MSC therapy, when delivered in PEGylated fibrin, results in significantly higher mature blood vessel formation, which allows for greater functional recovery of skeletal muscle tissue as as ...[more]