Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.
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ABSTRACT:
SUBMITTER: Planello AC
PROVIDER: S-EPMC4941276 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.
Planello Aline C AC Singhania Rajat R Kron Ken J KJ Bailey Swneke D SD Roulois David D Lupien Mathieu M Line Sérgio R Peres SR de Souza Ana Paula AP De Carvalho Daniel D DD
Oncotarget 20160301 13
Chronic periodontitis (CP) is a chronic inflammatory disease independently associated with higher incidence of oral cavity squamous cell carcinoma (OSCC). However, the molecular mechanism responsible for this increased incidence is unknown. Here we profiled the DNA methylome of CP patients and healthy controls and compared to a large set of OSCC samples from TCGA. We observed a significant overlap between the altered DNA methylation patterns in CP and in OSCC, suggesting an emergence of a pre-ne ...[more]
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Email: rw.reya@duke.edu Keywords = medulloblastoma Keywords = brain tumor Keywords = pre-neoplastic Keywords = patched Keywords = hedgehog Keywords = migration Keywords = differentiation
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