Ontology highlight
ABSTRACT:
SUBMITTER: Jiao F
PROVIDER: S-EPMC4941331 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Jiao Feng F Hu Hai H Han Ting T Zhuo Meng M Yuan Cuncun C Yang Haiyan H Wang Lei L Wang Liwei L
Oncotarget 20160301 13
Previous studies showed that aberrant CDH1 or/and HDAC3 localization is essential for the progression of some human cancers. Here, we investigate the prognostic significance of aberrant CDH1 and HDAC3 localization in 84 pancreatic cancer patients. Our results show that increases in both membrane and cytoplasmic CDH1 correlate with lymph node metastasis (P = 0.026 and P < 0.001, respectively) and clinical stage (P = 0.020 and P < 0.001, respectively). Increased nuclear HDAC3 correlates with lymph ...[more]