Ontology highlight
ABSTRACT:
SUBMITTER: Peng P
PROVIDER: S-EPMC4941732 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Peng Peike P Wu Weicheng W Zhao Junjie J Song Shushu S Wang Xuefei X Jia Dongwei D Shao Miaomiao M Zhang Mingming M Li Lili L Wang Lan L Duan Fangfang F Zhao Ran R Yang Caiting C Wu Hao H Zhang Jie J Shen Zhenbin Z Ruan Yuanyuan Y Gu Jianxin J
Scientific reports 20160712
Calpain-8 and calpain-9 belong to the family of calcium-dependent cysteine proteases, which are highly expressed in the stomach. However, the roles of calpain-8 and calpain-9 in gastric tumorigenesis remain little understood. Herein, we demonstrated that calpain-9 was generally decreased in gastric cancer cell lines and primary tumor tissues, while calpain-8 expression was not significantly altered. Calpain-9, but not calpain-8, induced cell cycle arrest in the G1 phase and cellular apoptosis in ...[more]