Ontology highlight
ABSTRACT:
SUBMITTER: Duan F
PROVIDER: S-EPMC5122401 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Duan Fangfang F Jia Dongwei D Zhao Junjie J Wu Weicheng W Min Lingqiang L Song Shushu S Wu Hao H Wang Lan L Wang Hongshan H Ruan Yuanyuan Y Gu Jianxin J
Oncotarget 20160601 25
Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and invasion and metastasis of gastric cancer represent the major reason for its poor prognosis. Glutamine: fructose-6-phosphate amidotransferase 1 (GFAT1) is the first and rate-limiting enzyme of hexosamine biosynthesis pathway (HBP). Nevertheless, the role of GFAT1 in gastric cancer is little investigated. In this study, we found that the expression of GFAT1 was decreased in gastric cancer. Low expression of ...[more]