Browse
Submit Data
Databases
API
Help

Dataset Information

42 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO₂/ZnGa₂O₄:Cr³⁺ Persistent Luminescence Nanocomposites.

ABSTRACT: Near-infrared (NIR) persistent phosphor ZnGa₂O₄:Cr³⁺ (ZGC) has unique deep-tissue rechargeable afterglow properties. However, the current synthesis leads to agglomerated products with irregular morphologies and wide size distributions. Herein, we report on in vivo rechargeable mesoporous SiO₂/ZnGa₂O₄:Cr³⁺ (mZGC) afterglow NIR-emitting nanocomposites that are made by a simple, one-step mesoporous template method. At less than 600 °C, pores in mesoporous silica nanoparticles (MSNs) act as nanoreactors to generate in situ ZnGa₂O₄:Cr³⁺ NIR-persistent phosphors. The as-synthesized mZGC preserves defined size, morphology, and mesoporous nanostructure of the MSNs. The persistent luminescence of the as-synthesized mZGC is recharged in a simulated deep-tissue environment (e.g., ≈8 mm pork slab) in vitro by using red light (620 nm). Moreover, mZGC can be repeatedly activated in vivo for persistent luminescence imaging in a live mouse model by using white LED as a light source. Our concept of utilizing mesoporous silica as nanoreactor to fabricate ZGC PL nanoparticles with controllable morphology and preserved porous nanostructure paves a new way to the development and the wide application of deep tissue rechargeable ZGC in photonics and biophotonics.

SUBMITTER: Li Z

PROVIDER: S-EPMC4941782 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Triggering near-infrared luminescence of vanadyl phthalocyanine by charging.

Project description:Probing electrofluorochromism (EFC) at the molecular level remains challenging. Here we study the strongly charge state-dependent photoluminescence of vanadyl phthalocyanine. We report vibrationally resolved absorption and laser-induced fluorescence (LIF) spectra of samples comprising both the mass-selected neutral molecule (VOPc⋅, a stable radical) and its cation produced upon electron ionization (EI) isolated in 5 K neon matrices. Ionization of the essentially non-emissive VOPc⋅ forms a high-spin diradical cation (VOPc+.. ) which shows profound photoluminescence (PL) in the NIR range. This unique phenomenon is potentially of interest for NIR-emitting electro-optic devices.

| S-EPMC9322020 | biostudies-literature

LaAlO?:Mn4+ as Near-Infrared Emitting Persistent Luminescence Phosphor for Medical Imaging: A Charge Compensation Study.

Project description:Mn4+-activated phosphors are emerging as a novel class of deep red/near-infrared emitting persistent luminescence materials for medical imaging as a promising alternative to Cr3+-doped nanomaterials. Currently, it remains a challenge to improve the afterglow and photoluminescence properties of these phosphors through a traditional high-temperature solid-state reaction method in air. Herein we propose a charge compensation strategy for enhancing the photoluminescence and afterglow performance of Mn4+-activated LaAlO? phosphors. LaAlO?:Mn4+ (LAO:Mn4+) was synthesized by high-temperature solid-state reaction in air. The charge compensation strategies for LaAlO?:Mn4+ phosphors were systematically discussed. Interestingly, Cl-/Na?/Ca2+/Sr2+/Ba2+/Ge4+ co-dopants were all found to be beneficial for enhancing LaAlO?:Mn4+ luminescence and afterglow intensity. This strategy shows great promise and opens up new avenues for the exploration of more promising near-infrared emitting long persistent phosphors for medical imaging.

| S-EPMC5744357 | biostudies-literature

Near-Infrared Quantum Cutting Long Persistent Luminescence.

Project description:By combining the unique features of the quantum cutting luminescence and long persistent luminescence, we design a new concept called "near-infrared quantum cutting long persistent luminescence (NQPL)", which makes it possible for us to obtain highly efficient (>100%) near-infrared long persistent luminescence in theory. Guided by the NQPL concept, we fabricate the first NQPL phosphor Ca2Ga2GeO7:Pr(3+),Yb(3+). It reveals that both the two-step energy transfer of model (I) and the one-step energy transfer of model (IV) occur in (3)P0 levels of Pr(3+). Although the actual efficiency is not sufficient for the practical application at this primitive stage, this discovery and the associated materials are still expected to have important implications for several fields such as crystalline Si solar cells and bio-medical imaging.

| S-EPMC4855154 | biostudies-literature

Nanoprobes with near-infrared persistent luminescence for in vivo imaging.

Project description:Fluorescence is increasingly used for in vivo imaging and has provided remarkable results. Yet this technique presents several limitations, especially due to tissue autofluorescence under external illumination and weak tissue penetration of low wavelength excitation light. We have developed an alternative optical imaging technique by using persistent luminescent nanoparticles suitable for small animal imaging. These nanoparticles can be excited before injection, and their in vivo distribution can be followed in real-time for more than 1 h without the need for any external illumination source. Chemical modification of the nanoparticles' surface led to lung or liver targeting or to long-lasting blood circulation. Tumor mass could also be identified on a mouse model.

| S-EPMC1890483 | biostudies-literature

Sensitized Yb3+ Luminescence in CsPbCl3 Film for Highly Efficient Near-Infrared Light-Emitting Diodes.

Project description:Near-infrared (NIR) light emitting diodes (LEDs) with the emission wavelength over 900 nm are useful in a wide range of optical applications. Narrow bandgap NIR emitters have been widely investigated using organic compounds and colloidal quantum dots. However, intrinsically low charge mobility and luminescence efficiency of these materials limit improvement of the external quantum efficiency (EQE) of NIR LEDs, which is far from practical applications. Herein, a highly efficient NIR LED is demonstrated, which is based on an energy transfer from wide bandgap all inorganic perovskite (CsPbCl3) to ytterbium ions (Yb3+) as an NIR emitter doped in the perovskite crystalline film. High mobility of electrically excited carriers in the perovskite crystalline film provides a long carrier diffusion and enhances radiative recombination of an emission center due to minimized charge trapping losses, resulting in high EQE value in LEDs. The NIR emission of Yb3+ at around 1000 nm is found to be sensitized by CsPbCl3 thin film with a photoluminescence quantum yield over 60%. The LED based on Yb3+-doped CsPbCl3 film exhibits a high EQE of 5.9% with a peak wavelength of 984 nm, achieved by high carrier transporting ability and effective sensitized emission property in the solid-film structure.

| S-EPMC7029626 | biostudies-literature

Semiconducting Polymer Nanoparticles with Persistent Near-Infrared Luminescence for In Vivo Optical Imaging.

Project description:Materials with persistent luminescence are attractive for in?vivo optical imaging since they have a long lifetime that allows the separation of excitation of fluorophores and image acquisition for time-delay imaging, thus eliminating tissue autofluorescence associated with fluorescence imaging. Persistently luminescent nanoparticles have previously been fabricated from toxic rare-earth metals. This work reports that nanoparticles made of the conjugated polymer MEH-PPV can generate luminescence persisting for an hour upon single excitation. A near-infrared dye was encapsulated in the conjugated polymer nanoparticle to successfully generate persistent near-infrared luminescence through resonance energy transfer. This new persistent luminescence nanoparticles have been demonstrated for optical imaging applications in living mice.

| S-EPMC4575640 | biostudies-literature

Near-infrared-emitting nanoparticles activate collagen synthesis via TGFβ signaling

Project description:We describe the novel synthesis Ag2S nanoparticles (NPs) by using a sonochemical method and reveal the effects of NIR irradiation on the enhancement of the production of collagen through NIR-emitting Ag2S NPs. We also synthesized Li-doped Ag2S NPs that exhibited significantly increased emission intensity because of their enhanced absorption ability in the UV - NIR region.

2020-07-25 | GSE155027 | GEO

Tunable long persistent luminescence in the second near-infrared window via crystal field control.

Project description:Construction of an active composite as a biomarker with deeper tissue penetration and higher signal-to-noise ratio (SNR) is of great importance for the application in bioimaging. Here, we report a strategy for tuning the emission bandwidth and intensity via crystal field control in long persistent phosphors (LPPs). Ni2+-doped Zn1+ySnyGa2-x-2yO4 phosphors, with a tunable emission band peaking from 1270 to 1430?nm in the second near-infrared (NIR) window, have been successfully prepared. Such featured materials have the advantages of low absorption and scattering as well as more efficient tissue penetration. The emission spectra can be controlled by tailoring the local crystal field around the activator precisely via substitution of Zn and Sn for Ga. Moreover, with high resolution and weak light disturbance, these developed multi-band afterglow phosphors exhibit great application potential in advanced optical imaging.

| S-EPMC5622036 | biostudies-literature

Facile Synthesis of Mn4+-Activated Double Perovskite Germanate Phosphors with Near-Infrared Persistent Luminescence.

Project description:Tetravalent manganese doped phosphors are emerging as a new class of efficient near-infrared emitters for applications in a variety of areas, such as bioimaging and night-vision surveillance. Novel double perovskite-type La2MgGeO6:Mn4+ phosphors were successfully prepared using a microwave-assisted energy-saving solid state method. This simple technique involving the use of a microwave susceptor allows for a reduction of the preparation time compared to a conventional solid state reaction. The samples were investigated using powder X-ray diffraction, scanning electron microscopy, as well as energy-dispersive X-ray spectroscopy mapping, photoluminescence excitation/emission spectroscopy, persistent luminescence decay and temperature-dependent photoluminescence analysis. Substitution between isovalent Mn4+ and Ge4+ can be achieved without additional charge compensators in this germanate-based phosphor, which provides strong emission in the near-infrared spectral region, assigned to the characteristic transitions of tetravalent manganese ions. Additionally, the double perovskite-type germanate phosphor exhibits excellent luminescence thermal stability. Moreover, the spectroscopic properties, excitation wavelength-dependent and temperature-dependent persistent luminescence were studied. A series of thermoluminescence measurements were presented trying to give clear information on the charging process, afterglow behavior and the nature of the traps responsible for the persistent luminescence. The present investigation expands the range of available promising near-infrared emitting persistent phosphors for medical imaging.

| S-EPMC6955683 | biostudies-literature

Long-term in vivo biodistribution and toxicity study of functionalized near-infrared persistent luminescence nanoparticles.

Project description:Near-infrared (NIR) persistent luminescence nanoparticles (NPLNPs) have become one of the most promising candidates for bioimaging. Different from the other fluorescence nanoprobes, the NIR persistent luminescence of NPLNPs can last for a long time after excitation, double exposure that is nanoparticles and light exist during the long-term bioimaging. However, to date, the potential risk of nanoparticles and NIR persistent luminescence of NPLNPs is still unknown. In this study, Cr3?+?-doped zinc gallate, Zn1.1Ga1.8Sn0.1O4:Cr3+ (ZGO), the most promising NPLNPs in bioimaging, was chosen as a representative for potential risk assessment. We evaluated the potential risk of nanoparticles and NIR persistent luminescence of ZGO for a long period of time. In vitro study showed that the ZGO possessed a low cytotoxicity. In vivo biodistribution results showed that the ZGO mainly accumulated in the reticuloendothelial system after intravenous injection and could be gradually cleared from the body by digestive system. In addition, the ZGO did not exhibit appreciable toxicity in mice over a period of 60 days. It's also worth mentioning that long-term NIR persistent luminescence of ZGO did not exhibit obvious toxicities both in vitro and in vivo. Our results provide important information with regards to the risk of NPLNPs in long-term bioimaging.

| S-EPMC6045641 | biostudies-literature