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In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO₂/ZnGa₂O₄:Cr³⁺ Persistent Luminescence Nanocomposites.

ABSTRACT: Near-infrared (NIR) persistent phosphor ZnGa₂O₄:Cr³⁺ (ZGC) has unique deep-tissue rechargeable afterglow properties. However, the current synthesis leads to agglomerated products with irregular morphologies and wide size distributions. Herein, we report on in vivo rechargeable mesoporous SiO₂/ZnGa₂O₄:Cr³⁺ (mZGC) afterglow NIR-emitting nanocomposites that are made by a simple, one-step mesoporous template method. At less than 600 °C, pores in mesoporous silica nanoparticles (MSNs) act as nanoreactors to generate in situ ZnGa₂O₄:Cr³⁺ NIR-persistent phosphors. The as-synthesized mZGC preserves defined size, morphology, and mesoporous nanostructure of the MSNs. The persistent luminescence of the as-synthesized mZGC is recharged in a simulated deep-tissue environment (e.g., ≈8 mm pork slab) in vitro by using red light (620 nm). Moreover, mZGC can be repeatedly activated in vivo for persistent luminescence imaging in a live mouse model by using white LED as a light source. Our concept of utilizing mesoporous silica as nanoreactor to fabricate ZGC PL nanoparticles with controllable morphology and preserved porous nanostructure paves a new way to the development and the wide application of deep tissue rechargeable ZGC in photonics and biophotonics.

SUBMITTER: Li Z

PROVIDER: S-EPMC4941782 | biostudies-literature |

REPOSITORIES: biostudies-literature

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