Ontology highlight
ABSTRACT:
SUBMITTER: Verity EE
PROVIDER: S-EPMC4942080 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Verity Erin E EE Camuglia Sarina S Agius Catherine T CT Ong Chi C Shaw Robert R Barr Ian I Middleton Deborah D Rockman Steven S
Influenza and other respiratory viruses 20110719 2
<h4>Background</h4>Vaccination is considered the most effective means of reducing influenza burden. The emergence of H5N1 and pandemic spread of novel H1N1/2009 viruses reinforces the need to have strategies in place to rapidly develop seed viruses for vaccine manufacture.<h4>Methods</h4>Candidate pandemic vaccine strains consisting of the circulating strain haemagglutinin (HA) and neuraminidase (NA) in an A/PR/8/34 backbone were generated using alternative synthetic DNA approaches, including si ...[more]