Ontology highlight
ABSTRACT:
SUBMITTER: Kang C
PROVIDER: S-EPMC4942138 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150901 6255
Cellular senescence is a terminal stress-activated program controlled by the p53 and p16(INK4a) tumor suppressor proteins. A striking feature of senescence is the senescence-associated secretory phenotype (SASP), a pro-inflammatory response linked to tumor promotion and aging. We have identified the transcription factor GATA4 as a senescence and SASP regulator. GATA4 is stabilized in cells undergoing senescence and is required for the SASP. Normally, GATA4 is degraded by p62-mediated selective a ...[more]