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Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.


ABSTRACT: BACKGROUND:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). METHODS:In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p?

SUBMITTER: Staley LA 

PROVIDER: S-EPMC4943503 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.

Staley Lyndsay A LA   Ebbert Mark T W MT   Parker Sheradyn S   Bailey Matthew M   Ridge Perry G PG   Goate Alison M AM   Kauwe John S K JS  

BMC genomics 20160629


<h4>Background</h4>Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF).<h4>Methods</h4>In this study, we measured prolactin levels in both plasma  ...[more]

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