Ontology highlight
ABSTRACT:
SUBMITTER: Hu H
PROVIDER: S-EPMC5948839 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
BMC medical genetics 20180511 1
<h4>Background</h4>The activity of cerebrospinal fluid (CSF) β-site APP cleaving enzyme (BACE) is a potential diagnostic biomarker for Alzheimer disease (AD).<h4>Methods</h4>A total of 340 non-Hispanic Caucasian participants from the Alzheimer's Disease Neuroimaging Initiative cohort (ADNI) database were included in this study with quality-controlled CSF BACE and genotype data. Association of CSF BACE with the genetic variants of single nucleotide polymorphisms (SNPs) was assessed using PLINK un ...[more]