Ontology highlight
ABSTRACT:
SUBMITTER: Bhumiratana S
PROVIDER: S-EPMC4944852 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Bhumiratana Sarindr S Bernhard Jonathan C JC Alfi David M DM Yeager Keith K Eton Ryan E RE Bova Jonathan J Shah Forum F Gimble Jeffrey M JM Lopez Mandi J MJ Eisig Sidney B SB Vunjak-Novakovic Gordana G
Science translational medicine 20160601 343
Facial deformities require precise reconstruction of the appearance and function of the original tissue. The current standard of care-the use of bone harvested from another region in the body-has major limitations, including pain and comorbidities associated with surgery. We have engineered one of the most geometrically complex facial bones by using autologous stromal/stem cells, native bovine bone matrix, and a perfusion bioreactor for the growth and transport of living grafts, without bone mor ...[more]