Ontology highlight
ABSTRACT:
SUBMITTER: Novkovic M
PROVIDER: S-EPMC4945005 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Novkovic Mario M Onder Lucas L Cupovic Jovana J Abe Jun J Bomze David D Cremasco Viviana V Scandella Elke E Stein Jens V JV Bocharov Gennady G Turley Shannon J SJ Ludewig Burkhard B
PLoS biology 20160714 7
Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and establish distinct microenvironmental niches to provide key molecules that drive innate and adaptive immune responses and control immune regulatory processes. Here, we have used a graph theory-based systems biology approach to determine topological properties and robustness of the LN FRC network in mice. We found that the FRC network exhibits an imprinted small-world topology that is fully regenerated within ...[more]