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Rhodium(I)-Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles.

ABSTRACT: A de novo synthesis of a benzene ring allows for the preparation of a diverse range of heterocycles including indoles, benzofurans, benzothiophenes, carbazoles, and dibenzofurans from simple heteroaryl propargylic esters using a unified carbonylative benzannulation strategy. Multiple substituents can be easily introduced to the C4-C7 positions of indoles and related heterocycles.

SUBMITTER: Li X

PROVIDER: S-EPMC4945426 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Rhodium(I)-Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles.

Li Xiaoxun X Xie Haibo H Fu Xiaoning X Liu Ji-Tian JT Wang Hao-Yuan HY Xi Bao-Min BM Liu Peng P Xu Xiufang X Tang Weiping W

Chemistry (Weinheim an der Bergstrasse, Germany) 20160620 30

A de novo synthesis of a benzene ring allows for the preparation of a diverse range of heterocycles including indoles, benzofurans, benzothiophenes, carbazoles, and dibenzofurans from simple heteroaryl propargylic esters using a unified carbonylative benzannulation strategy. Multiple substituents can be easily introduced to the C4-C7 positions of indoles and related heterocycles. ...[more]

PMID: 27189811

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