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Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters.

ABSTRACT: Pt(II)-catalyzed cycloisomerization of aziridinyl propargylic esters affords 1,2-dihydropyridines with regiodefined installation of substituents. A mild conversion of the 1,2-dihydropyridines to the corresponding substituted pyridines as well as chirality retention from the aziridinyl propargylic ester substrates have been demonstrated.

SUBMITTER: Motamed M

PROVIDER: S-EPMC3384524 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

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Pt(II)-catalyzed synthesis of 1,2-dihydropyridines from aziridinyl propargylic esters.

Motamed Massoud M Bunnelle Eric M EM Singaram Surendra W SW Sarpong Richmond R

Organic letters 20070424 11

Pt(II)-catalyzed cycloisomerization of aziridinyl propargylic esters affords 1,2-dihydropyridines with regiodefined installation of substituents. A mild conversion of the 1,2-dihydropyridines to the corresponding substituted pyridines as well as chirality retention from the aziridinyl propargylic ester substrates have been demonstrated. ...[more]

PMID: 17451249

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