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The Role of TGF-? in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

ABSTRACT: Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome (BOS) following lung transplantation; however, the mechanism for any such association is poorly understood. Based on the association of TGF-? with acute and chronic inflammatory disorders, we hypothesized that it might play a role in the continuum between PGD and BOS. Thus, the association between PGD and BOS was assessed in a single-center cohort of lung transplant recipients. Bronchoalveolar lavage fluid concentrations of TGF-? and procollagen collected within 24?h of transplantation were compared across the spectrum of PGD, and incorporated into Cox models of BOS. Immunohistochemistry localized expression of TGF-? and its receptor in early lung biopsies posttransplant. We found an association between PGD and BOS in both bilateral and single lung recipients with a hazard ratio of 3.07 (95% CI 1.76-5.38) for the most severe form of PGD. TGF-? and procollagen concentrations were elevated during PGD (p?

SUBMITTER: DerHovanessian A 

PROVIDER: S-EPMC4946573 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

DerHovanessian A A   Weigt S S SS   Palchevskiy V V   Shino M Y MY   Sayah D M DM   Gregson A L AL   Noble P W PW   Palmer S M SM   Fishbein M C MC   Kubak B M BM   Ardehali A A   Ross D J DJ   Saggar R R   Lynch J P JP   Elashoff R M RM   Belperio J A JA  

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20151013 2

Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome (BOS) following lung transplantation; however, the mechanism for any such association is poorly understood. Based on the association of TGF-β with acute and chronic inflammatory disorders, we hypothesized that it might play a role in the continuum between PGD and BOS. Thus, the association between PGD and BOS was assessed in a single-center cohort of lung transplant recipients. Bronchoalveolar lavage  ...[more]

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