Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC4947155 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Yang Ying Y Wang Zhi-Hao ZH Jin Sen S Gao Di D Liu Nan N Chen Shan-Ping SP Zhang Sinan S Liu Qing Q Liu Enjie E Wang Xin X Liang Xiao X Wei Pengfei P Li Xiaoguang X Li Yin Y Yue Chenyu C Li Hong-Lian HL Wang Ya-Li YL Wang Qun Q Ke Dan D Xie Qingguo Q Xu Fuqiang F Wang Liping L Wang Jian-Zhi JZ
Nature communications 20160714
Different emotional states lead to distinct behavioural consequences even when faced with the same challenging events. Emotions affect learning and memory capacities, but the underlying neurobiological mechanisms remain elusive. Here we establish models of learned helplessness (LHL) and learned hopefulness (LHF) by exposing animals to inescapable foot shocks or with anticipated avoidance trainings. The LHF animals show spatial memory potentiation with excitatory monosynaptic upscaling between po ...[more]