Ontology highlight
ABSTRACT:
SUBMITTER: Lau OC
PROVIDER: S-EPMC4947175 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Lau On-Chai OC Shen Bing B Wong Ching-On CO Tjong Yung-Wui YW Lo Chun-Yin CY Wang Hui-Chuan HC Huang Yu Y Yung Wing-Ho WH Chen Yang-Chao YC Fung Man-Lung ML Rudd John Anthony JA Yao Xiaoqiang X
Nature communications 20160714
Blood pressure is maintained within a normal physiological range by a sophisticated regulatory mechanism. Baroreceptors serve as a frontline sensor to detect the change in blood pressure. Nerve signals are then sent to the cardiovascular control centre in the brain in order to stimulate baroreflex responses. Here, we identify TRPC5 channels as a mechanical sensor in aortic baroreceptors. In Trpc5 knockout mice, the pressure-induced action potential firings in the afferent nerve and the barorefle ...[more]