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Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells.


ABSTRACT: The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

SUBMITTER: Walter T 

PROVIDER: S-EPMC4947872 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells.

Walter T T   Collenburg L L   Japtok L L   Kleuser B B   Schneider-Schaulies S S   Müller N N   Becam J J   Schubert-Unkmeir A A   Kong J N JN   Bieberich E E   Seibel J J  

Chemical communications (Cambridge, England) 20160601 55


The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells. ...[more]

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