Ontology highlight
ABSTRACT:
SUBMITTER: Stepanova LA
PROVIDER: S-EPMC4947995 | biostudies-literature | 2016 Apr-Jun
REPOSITORIES: biostudies-literature
Stepanova L A LA Sergeeva M V MV Shuklina M A MA Shaldzhyan A A AA Potapchuk M V MV Korotkov A V AV Tsybalova L M LM
Acta naturae 20160401 2
Conserved fragments of the second subunit of hemagglutinin (HA2) are of great interest for the design of vaccine constructs that can provide protective immunity against influenza A viruses of different subtypes. A recombinant fusion protein, FlgMH, was constructed on the basis of flagellin and a highly conserved HA2 fragment (35-107) of influenza viruses of the subtype A/H2N2, containing B cell, CD4+ T cell, and CD8+ T cell epitopes. The native conformation of the HA2 fragment was partially pres ...[more]