Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects.
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ABSTRACT:
SUBMITTER: Al-Samhari MM
PROVIDER: S-EPMC4950483 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects.
Al-Samhari Marwa M MM Al-Rasheed Nouf M NM Al-Rejaie Salim S Al-Rasheed Nawal M NM Hasan Iman H IH Mahmoud Ayman M AM Dzimiri Nduna N
Experimental biology and medicine (Maywood, N.J.) 20151206 5
Advances in depression research have targeted inflammation and oxidative stress to develop novel types of treatment. The JAK/STAT signaling pathway plays pivotal roles in immune and inflammatory responses. The present study was designed to investigate the effects of N-acetylcysteine, a putative precursor of the antioxidant glutathione, in an animal model of depression, with an emphasis on the JAK/STAT signaling pathway. Fluoxetine, a classical antidepressant drug was also under investigation. Ma ...[more]
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