Ontology highlight
ABSTRACT:
SUBMITTER: Molnar J
PROVIDER: S-EPMC4951166 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Molnár Judit J Fazakas Csilla C Haskó János J Sipos Orsolya O Nagy Krisztina K Nyúl-Tóth Ádám Á Farkas Attila E AE Végh Attila G AG Váró György G Galajda Péter P Krizbai István A IA Wilhelm Imola I
Cell adhesion & migration 20151208 3
Brain metastases are common and devastating complications of both breast cancer and melanoma. Although mammary carcinoma brain metastases are more frequent than those originating from melanoma, this latter has the highest tropism to the brain. Using static and dynamic in vitro approaches, here we show that melanoma cells have increased adhesion to the brain endothelium in comparison to breast cancer cells. Moreover, melanoma cells can transmigrate more rapidly and in a higher number through brai ...[more]