Unknown

Dataset Information

0

Capillary-induced Homogenization of Matrix in Paper: A Powerful Approach for the Quantification of Active Pharmaceutical Ingredients Using Mass Spectrometry Imaging.


ABSTRACT: Herein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously "eluted" with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry imaging (MSI) and quantification through characteristic fingerprints is ultimately performed. Results for the content of rosuvastatin from a known formulation are comparable to those obtained with a validated HPLC method.

SUBMITTER: de Menezes M 

PROVIDER: S-EPMC4954946 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7036234 | biostudies-literature
| S-EPMC10848412 | biostudies-literature
| S-EPMC5761121 | biostudies-literature
| S-EPMC6641490 | biostudies-literature
| S-EPMC7675532 | biostudies-literature
| S-EPMC7329761 | biostudies-literature
| S-EPMC8153937 | biostudies-literature
| S-EPMC5698727 | biostudies-literature
| S-EPMC9764418 | biostudies-literature