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Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses.


ABSTRACT: Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the prognostic impact of the American Joint Committee on Cancer (AJCC) response criteria and this tool's usefulness in four different breast cancer subtypes.We conducted a retrospective cohort study of clinical stage II/III breast cancer patients who received NAC of more than 6 cycles. Response after NAC and the clinicopathological factors were reviewed. AJCC response criteria for NAC were adopted from the AJCC Manual, 7th edition: complete response (CR), partial response (PR), and no response (NR).A total of 183 patients were enrolled; 22 (12.0 %), 123 (67.2 %), and 38 (20.8 %) patients showed CR, PR, and NR, respectively. The AJCC response was significantly associated with relapse-free survival (RFS) (P?

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4955253 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Prognostic impact of AJCC response criteria for neoadjuvant chemotherapy in stage II/III breast cancer patients: breast cancer subtype analyses.

Yang Yaewon Y   Im Seock-Ah SA   Keam Bhumsuk B   Lee Kyung-Hun KH   Kim Tae-Yong TY   Suh Koung Jin KJ   Ryu Han Suk HS   Moon Hyeong-Gon HG   Han Sae-Won SW   Oh Do-Youn DY   Han Wonshik W   Kim Tae-You TY   Park In Ae IA   Noh Dong-Young DY  

BMC cancer 20160721


<h4>Background</h4>Neoadjuvant chemotherapy (NAC) is a standard treatment for stage II/III breast cancer patients, and response to NAC is a useful prognostic marker. Since its introduction, 6-8 cycles of NAC has become the standard regimen to improve the outcome of these patients. The purpose of this study is to evaluate the prognostic impact of the American Joint Committee on Cancer (AJCC) response criteria and this tool's usefulness in four different breast cancer subtypes.<h4>Methods</h4>We c  ...[more]

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