Ontology highlight
ABSTRACT:
SUBMITTER: Park YH
PROVIDER: S-EPMC4955684 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Park Yong Hwan YH Wood Geryl G Kastner Daniel L DL Chae Jae Jin JJ
Nature immunology 20160606 8
Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause distinct interleukin-1β (IL-1β)-mediated autoinflammatory diseases: familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS). Pyrin forms an inflammasome when mutant or in response to bacterial modification of the GTPase RhoA. We found that RhoA activated the serine-threonine kinases PKN1 and PKN2 that bind and phosphorylate pyrin. Phosphorylated pyrin bound to 14-3-3 proteins, regulatory proteins tha ...[more]