Ontology highlight
ABSTRACT:
SUBMITTER: Mohana S
PROVIDER: S-EPMC4955727 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Mohana S S Ganesan M M Agilan B B Karthikeyan R R Srithar G G Beaulah Mary R R Ananthakrishnan D D Velmurugan D D Rajendra Prasad N N Ambudkar Suresh V SV
Molecular bioSystems 20160701 8
P-Glycoprotein (P-gp) serves as a therapeutic target for the development of inhibitors to overcome multidrug resistance in cancer cells. Although various screening procedures have been practiced so far to develop first three generations of P-gp inhibitors, their toxicity and drug interaction profiles are still a matter of concern. To address the above important problem of developing safe and effective P-gp inhibitors, we have made systematic computational and experimental studies on the interact ...[more]