Ontology highlight
ABSTRACT:
SUBMITTER: Locci M
PROVIDER: S-EPMC4955732 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Locci Michela M Wu Jennifer E JE Arumemi Fortuna F Mikulski Zbigniew Z Dahlberg Carol C Miller Andrew T AT Crotty Shane S
Nature immunology 20160704 8
Follicular helper T cells (TFH cells) are CD4(+) T cells specialized in helping B cells and are associated both with protective antibody responses and autoimmune diseases. The promise of targeting TFH cells therapeutically has been limited by fragmentary understanding of extrinsic signals that regulate the differentiation of human TFH cells. A screen of a human protein library identified activin A as a potent regulator of TFH cell differentiation. Activin A orchestrated the expression of multipl ...[more]