Ontology highlight
ABSTRACT:
SUBMITTER: Temple KJ
PROVIDER: S-EPMC4955811 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20160615 15
Protein prenylation is a type of post-translational modification that aids certain proteins in localizing to the plasma member where they activate cell signaling. To better understand the isoprenoid requirements and differences of FTase and GGTase-I, a series of saturated geranylgeranyl diphosphate analogs were synthesized and screened against both mammalian FTase and GGTase-I. Of our library of compounds, several analogs proved to be substrates of GGTase-I, with 11d having a krel=0.95 when comp ...[more]