Ontology highlight
ABSTRACT:
SUBMITTER: Lau K
PROVIDER: S-EPMC4955842 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nature cell biology 20150420 5
The physical forces that drive morphogenesis are not well characterized in vivo, especially among vertebrates. In the early limb bud, dorsal and ventral ectoderm converge to form the apical ectodermal ridge (AER), although the underlying mechanisms are unclear. By live imaging mouse embryos, we show that prospective AER progenitors intercalate at the dorsoventral boundary and that ectoderm remodels by concomitant cell division and neighbour exchange. Mesodermal expansion and ectodermal tension t ...[more]