Dataset Information

Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection.

ABSTRACT:

Objective

To investigate the role of homocysteine in neuronal injury in HIV infection.

Methods

Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitamin B12, serum folate, CSF, and plasma HIV RNA, the immune activation marker neopterin in CSF and serum, and albumin ratio as a marker of blood-brain barrier integrity. Twenty-two subjects provided a second sample median of 12.5 months after antiretroviral treatment initiation.

Results

A significant correlation was found between plasma homocysteine and CSF NFL concentrations in untreated individuals (r = 0.52, p < 0.0001). As expected, there was a significant inverse correlation between homocysteine and B12 (r = -0.41, p < 0.001) and folate (r = -0.40, p = < 0.001) levels. In a multiple linear regression analysis homocysteine stood out as an independent predictor of CSF NFL in HIV-1-infected individuals. The correlation of plasma homocysteine and CSF NFL was also present in the group receiving antiretroviral therapy (r = 0.51, p = 0.016).

Conclusion

A correlation between plasma homocysteine and axonal injury, as measured by CSF NFL, was found in both untreated and treated HIV. While this study is not able to prove a causal link, homocysteine and functional B12/folate deficiency appear to play a role in neural injury in HIV-infected individuals.

SUBMITTER: Ahlgren E

PROVIDER: S-EPMC4956037 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection.

Ahlgren Erika E Hagberg Lars L Fuchs Dietmar D Andersson Lars-Magnus LM Nilsson Staffan S Zetterberg Henrik H Gisslén Magnus M

PloS one 20160721 7

<h4>Objective</h4>To investigate the role of homocysteine in neuronal injury in HIV infection.<h4>Methods</h4>Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitamin B12, serum folate, CSF, and plasma HIV RNA, the immune activation marker neopterin in C ...[more]

PMID: 27441551

Similar Datasets

Project description:BACKGROUND:Growing evidence indicates that homocysteine is a noteworthy marker for general health status. However, research regarding plasma total homocysteine (tHcy) levels and bone mineral density (BMD) is sparse and controversial. Hence, we aimed to investigate the association between plasma tHcy level within normal range and lumbar BMD in adults. METHODS:In this cross-sectional study, using the National Health and Nutrition Examination Survey database, data on 10748 adults aged between 30 and 85?years were analyzed. The weighted multiple logistic regression analyses were conducted to evaluate the association between plasma tHcy level and lumbar BMD. The fitted smoothing curves were performed to explore potential non-linear relationships. When non-linearity was detected, we further calculated the inflection point using a recursive algorithm and constructed a weighted two-piecewise linear regression model. RESULTS:After adjusting for all the covariates, the association between plasma tHcy and lumbar BMD was different in various age groups (adults aged 30-49?years: ? = -0.0004, 95% CI -0.0025, 0.0018; adults aged 50-69?years: ? = 0.0001, 95% CI -0.0025, 0.0026; adults aged 70-85?years: ? = 0.0050, 95% CI 0.0008, 0.0092). In the subgroup analysis stratified by gender, this association also differed based on gender. There was a negative trend in females (aged 30-49?years: ? = -0.0022, 95% CI -0.0054, 0.0011; aged 50-69?years: ? = -0.0028, 95% CI -0.0062, 0.0007), and a positive trend in males (aged 30-49?years: ? = 0.0018, 95% CI -0.0012, 0.0048; aged 50-69?years: ? = 0.0027, 95% CI -0.0009, 0.0063) in both 30-49?years group and 50-69?years group. In the 70-85?years group, this association was significantly positive in males (? = 0.0136, 95% CI 0.0068, 0.0204), but was not significantly different in females (? = 0.0007, 95% CI -0.0046, 0.0060). CONCLUSION:The correlation between plasma tHcy level within the normal range and lumbar BMD differs by age and gender.

Dataset Information

Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection.

Objective

Methods

Results

Conclusion

Publications

Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection.

Similar Datasets

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