Dataset Information

Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD.

ABSTRACT: Biomarkers for the progression of lung function in COPD are currently scarce. Plasma fetuin-B (FETUB) was identified by iTRAQ-based proteomics and was verified by ELISA in another group. Information regarding acute exacerbation (AE) was collected in a one-year follow-up programme. FETUB concentrations (1652?±?427?ng/ml) were greater in COPD patients than in controls (1237?±?77?ng/ml). The concentrations of FETUB in GOLD II (1762?±?427?ng/ml), III (1650?±?375?ng/ml) and IV (1800?±?451?ng/ml) groups were greater than those in the controls (1257?±?414?ng/ml) and the GOLD I (1345?±?391?ng/ml) group. ROCs indicated that FETUB distinguished COPD patients from controls (AUC 0.747, 95% CI: 0.642-0.834) and also GOLD II, III and IV from GOLD I COPD patients (AUC: 0.770, 95% CI: 0.634-0.874). The combination of FETUB and fibrinogen performed better (AUC: 0.804, 95% CI: 0.705-0.881). FETUB also predicted the occurrence of AE (AUC: 0.707, 95% CI: 0.566-0.824) or frequent AE (AUC: 0.727, 95% CI: 0.587-0.840). FETUB concentrations were negatively correlated with FEV1%pred (r?=?-0.446, p?=?0.000) and positively correlated with RV%pred (r?=?0.317, p?=?0.004), RV/TLC% (r?=?0.360, p?=?0.004), CT emphysema% (r?=?0.322, p?=?0.008) and grades of lung function (r?=?0.437, p?=?0.000). In conclusion, FETUB is likely to assist the diagnosis and management of COPD as a complement for other markers.

SUBMITTER: Diao WQ

PROVIDER: S-EPMC4957096 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD.

Diao Wen-Qi WQ Shen Ning N Du Yi-Peng YP Liu Bei-Bei BB Sun Xiao-Yan XY Xu Ming M He Bei B

Scientific reports 20160722

Biomarkers for the progression of lung function in COPD are currently scarce. Plasma fetuin-B (FETUB) was identified by iTRAQ-based proteomics and was verified by ELISA in another group. Information regarding acute exacerbation (AE) was collected in a one-year follow-up programme. FETUB concentrations (1652 ± 427 ng/ml) were greater in COPD patients than in controls (1237 ± 77 ng/ml). The concentrations of FETUB in GOLD II (1762 ± 427 ng/ml), III (1650 ± 375 ng/ml) and IV (1800 ± 451 ng/ml) grou ...[more]

PMID: 27443820

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Dataset Information

Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD.

Publications

Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD.

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