Ontology highlight
ABSTRACT:
SUBMITTER: Gongpan P
PROVIDER: S-EPMC4957568 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Gongpan Pianchou P Lu Yanting Y Wang Fang F Xu Yuhui Y Xiong Wenyong W
Cell cycle (Georgetown, Tex.) 20160506 13
AS160 (TBC1D4) has been implicated in multiple biological processes. However, the role and the mechanism of action of AS160 in the regulation of cell proliferation remain unclear. In this study, we demonstrated that AS160 knockdown led to blunted cell proliferation in multiple cell types, including fibroblasts and cancer cells. The results of cell cycle analysis showed that these cells were arrested in the G1 phase. Intriguingly, this inhibition of cell proliferation and the cell cycle arrest ca ...[more]