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Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects.

ABSTRACT: The results of studies investigating the association between the ladybird homeobox 1 (LBX1) gene polymorphisms and the risk of adolescent idiopathic scoliosis (AIS) are not all the same. As such, we performed a meta-analysis to estimate the association between LBX1 gene polymorphisms and AIS susceptibility.Relevant studies published before 15 November 2015 were identified by searching PubMed, EMBASE, ISI web of knowledge, EBSCO, CNKI and CBM. The strength of relationship was assessed by using odds ratios (ORs) and 95 % confidence interval (CI).A total number of eight case-control studies including 10,088 cases and 24,538 controls were identified. The results showed that T allele of rs111090870 increased AIS susceptibility in Asians (T vs. C, OR?=?1.22, 95 % CI: 1.16-1.29, P?

SUBMITTER: Cao Y

PROVIDER: S-EPMC4957912 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects.

Cao Yaqin Y Min Jikang J Zhang Qianghua Q Li Heng H Li Haidong H

BMC musculoskeletal disorders 20160722

<h4>Background</h4>The results of studies investigating the association between the ladybird homeobox 1 (LBX1) gene polymorphisms and the risk of adolescent idiopathic scoliosis (AIS) are not all the same. As such, we performed a meta-analysis to estimate the association between LBX1 gene polymorphisms and AIS susceptibility.<h4>Methods</h4>Relevant studies published before 15 November 2015 were identified by searching PubMed, EMBASE, ISI web of knowledge, EBSCO, CNKI and CBM. The strength of re ...[more]

PMID: 27450593

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The Susceptibility and Potential Functions of the LBX1 Gene in Adolescent Idiopathic Scoliosis.

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Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population.

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Haplotypes at LBX1 have distinct inheritance patterns with opposite effects in adolescent idiopathic scoliosis.

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Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population.

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