Shared and unique common genetic determinants between pediatric and adult celiac disease.

ABSTRACT: Based on age of presentation, celiac disease (CD) is categorised as pediatric CD and adult CD. It however remains unclear if these are genetically and/or phenotypically distinct disorders or just different spectrum of the same disease. We therefore explored the common genetic components underlying pediatric and adult CD in a well characterized north Indian cohort.A retrospective analysis of children (n?=?531) and adult (n?=?871) patients with CD between January 2001 and December 2010 was done. The database included basic demographic characteristics, clinical presentations, associated diseases and complications, if any. The genotype dataset was acquired for children (n?=?217) and adult CD patients (n?=?340) and controls (n?=?736) using Immunochip. Association analysis was performed using logistic regression model to identify susceptibility genetic variants.The predominant form of CD was classical CD in both pediatric and adult CD groups. There was remarkable similarity between pediatric and adult CD except for quantitative differences between the two groups such as female preponderance, non-classical presentation, co-occurrence of other autoimmune diseases being more common amongst adult CD. Notably, same HLA-DQ2 and -DQ8 haplotypes were established as the major risk factors in both types of CD. In addition, a few suggestively associated (p?

SUBMITTER: Senapati S 

PROVIDER: S-EPMC4957920 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature