Common shared genetic variation behind decreased risk of breast cancer in celiac disease.
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ABSTRACT:
SUBMITTER: Ugalde-Morales E
PROVIDER: S-EPMC5517429 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Common shared genetic variation behind decreased risk of breast cancer in celiac disease.
Ugalde-Morales Emilio E Li Jingmei J Humphreys Keith K Ludvigsson Jonas F JF Yang Haomin H Hall Per P Czene Kamila K
Scientific reports 20170719 1
There is epidemiologic evidence showing that women with celiac disease have reduced risk of later developing breast cancer, however, the etiology of this association is unclear. Here, we assess the extent of genetic overlap between the two diseases. Through analyses of summary statistics on densely genotyped immunogenic regions, we show a significant genetic correlation (r = -0.17, s.e. 0.05, P < 0.001) and overlap (P <sub>permuted</sub> < 0.001) between celiac disease and breast cancer. Using i ...[more]
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