Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4957924 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B.
Bioorganic & medicinal chemistry 20160317 15
Phosphotyrosine peptides are useful starting points for inhibitor design and for the search for protein tyrosine phosphatase (PTP) phosphoprotein substrates. To identify novel phosphopeptide substrates of PTP1B, we developed a computational prediction protocol based on a virtual library of protein sequences with known phosphotyrosine sites. To these we applied sequence-based methods, biologically meaningful filters and molecular docking. Five peptides were selected for biochemical testing of the ...[more]
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