Ontology highlight
ABSTRACT:
SUBMITTER: Hongdusit A
PROVIDER: S-EPMC7005756 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hongdusit Akarawin A Zwart Peter H PH Sankaran Banumathi B Fox Jerome M JM
Nature communications 20200207 1
Protein tyrosine phosphatases regulate a myriad of essential subcellular signaling events, yet they remain difficult to study in their native biophysical context. Here we develop a minimally disruptive optical approach to control protein tyrosine phosphatase 1B (PTP1B)-an important regulator of receptor tyrosine kinases and a therapeutic target for the treatment of diabetes, obesity, and cancer-and we use that approach to probe the intracellular function of this enzyme. Our conservative architec ...[more]