Ontology highlight
ABSTRACT:
SUBMITTER: Yang T
PROVIDER: S-EPMC4958167 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Yang Tuo T Xie Stanley C SC Cao Pengxing P Giannangelo Carlo C McCaw James J Creek Darren J DJ Charman Susan A SA Klonis Nectarios N Tilley Leann L
Antimicrobial agents and chemotherapy 20160722 8
Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been approved for marketing or are currently in clinical development. We undertook an analysis of the kinetics of the in vitro responses of Plasmodium falciparum to the new ozonide antimalarials. For these studies we used a K13 mutant (artemisinin resistant) isolate from a region in Cambodia and a genetically matched (artemisinin sensitive) K13 revertant. We used a pulsed- ...[more]