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Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.

ABSTRACT: We report the complete nucleotide sequence of a plasmid, pA31-12, carrying blaCTX-M-55 and mcr-1 from a chicken Escherichia coli isolate. pA31-12 has an IncI2 replicon that displays extensive sequence similarity with pHN1122-1-borne blaCTX-M-55 and pHNSHP45-borne mcr-1 Insertion sequences ISEcp1 and ISApl1 are responsible for the mobilization of blaCTX-M-55 and mcr-1, respectively. The colocalization of mcr-1 with an extended-spectrum ?-lactamase gene on a conjugative plasmid may accelerate the dissemination of both genes by coselection.

SUBMITTER: Sun J

PROVIDER: S-EPMC4958226 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.

Sun Jian J Li Xing-Ping XP Yang Run-Shi RS Fang Liang-Xing LX Huo Wei W Li Shu-Min SM Jiang Peng P Liao Xiao-Ping XP Liu Ya-Hong YH

Antimicrobial agents and chemotherapy 20160722 8

We report the complete nucleotide sequence of a plasmid, pA31-12, carrying blaCTX-M-55 and mcr-1 from a chicken Escherichia coli isolate. pA31-12 has an IncI2 replicon that displays extensive sequence similarity with pHN1122-1-borne blaCTX-M-55 and pHNSHP45-borne mcr-1 Insertion sequences ISEcp1 and ISApl1 are responsible for the mobilization of blaCTX-M-55 and mcr-1, respectively. The colocalization of mcr-1 with an extended-spectrum β-lactamase gene on a conjugative plasmid may accelerate the ...[more]

PMID: 27216063

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