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Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid.

ABSTRACT: We report the genetic and functional characterization of a novel CTX-M-199 ?-lactamase, which was encoded by a blaCTX-M-64 variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to ?-lactamase inhibitors, tazobactam, and sulbactam.

SUBMITTER: Cai J

PROVIDER: S-EPMC5487609 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid.

Cai Jiachang J Cheng Qipeng Q Shen Yingbo Y Gu Danxia D Fang Ying Y Chan Edward Wai-Chi EW Chen Sheng S

Antimicrobial agents and chemotherapy 20170627 7

We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64 variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam. ...[more]

PMID: 28483954

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