Ontology highlight
ABSTRACT:
SUBMITTER: Wolf C
PROVIDER: S-EPMC4958374 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Wolf Clancey C Siegel Justin B JB Tinberg Christine C Camarca Alessandra A Gianfrani Carmen C Paski Shirley S Guan Rongjin R Montelione Gaetano G Baker David D Pultz Ingrid S IS
Journal of the American Chemical Society 20150929 40
Celiac disease is characterized by intestinal inflammation triggered by gliadin, a component of dietary gluten. Oral administration of proteases that can rapidly degrade gliadin in the gastric compartment has been proposed as a treatment for celiac disease; however, no protease has been shown to specifically reduce the immunogenic gliadin content, in gastric conditions, to below the threshold shown to be toxic for celiac patients. Here, we used the Rosetta Molecular Modeling Suite to redesign th ...[more]