Extreme sensitivity biosensing platform based on hyperbolic metamaterials.

ABSTRACT: Optical sensor technology offers significant opportunities in the field of medical research and clinical diagnostics, particularly for the detection of small numbers of molecules in highly diluted solutions. Several methods have been developed for this purpose, including label-free plasmonic biosensors based on metamaterials. However, the detection of lower-molecular-weight (<500?Da) biomolecules in highly diluted solutions is still a challenging issue owing to their lower polarizability. In this context, we have developed a miniaturized plasmonic biosensor platform based on a hyperbolic metamaterial that can support highly confined bulk plasmon guided modes over a broad wavelength range from visible to near infrared. By exciting these modes using a grating-coupling technique, we achieved different extreme sensitivity modes with a maximum of 30,000?nm per refractive index unit (RIU) and a record figure of merit (FOM) of 590. We report the ability of the metamaterial platform to detect ultralow-molecular-weight (244?Da) biomolecules at picomolar concentrations using a standard affinity model streptavidin-biotin.

SUBMITTER: Sreekanth KV 

PROVIDER: S-EPMC4959915 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature