Ontology highlight
ABSTRACT:
SUBMITTER: Randhawa S
PROVIDER: S-EPMC4959949 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Randhawa Shubhchintan S Cho Byung S BS Ghosh Dipanjan D Sivina Mariela M Koehrer Stefan S Müschen Markus M Peled Amnon A Davis Richard E RE Konopleva Marina M Burger Jan A JA
British journal of haematology 20160412 3
B cell acute lymphoblastic leukaemia (B-ALL) cells express high levels of CXCR4 chemokine receptors for homing and retention within the marrow microenvironment. Bone marrow stromal cells (BMSC) secrete CXCL12, the ligand for CXCR4, and protect B-ALL cells from cytotoxic drugs. Therefore, the therapeutic use of CXCR4 antagonists has been proposed to disrupt cross talk between B-ALL cells and the protective stroma. Because CXCR4 antagonists can have activating agonistic function, we compared the g ...[more]