Ontology highlight
ABSTRACT:
SUBMITTER: Penney J
PROVIDER: S-EPMC4960312 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Penney Jay J Tsurudome Kazuya K Liao Edward H EH Kauwe Grant G Gray Lindsay L Yanagiya Akiko A R Calderon Mario M Sonenberg Nahum N Haghighi A Pejmun AP
Nature communications 20160719
Parkinson's disease gene leucine-rich repeat kinase 2 (LRRK2) has been implicated in a number of processes including the regulation of mitochondrial function, autophagy and endocytic dynamics; nevertheless, we know little about its potential role in the regulation of synaptic plasticity. Here we demonstrate that postsynaptic knockdown of the fly homologue of LRRK2 thwarts retrograde, homeostatic synaptic compensation at the larval neuromuscular junction. Conversely, postsynaptic overexpression o ...[more]